Level 12 DiseaseEdit

The symptoms of cackle fever include high fever, disorientation, and frequent bouts of hideous laughter.

Attack: +16 vs. Fortitude
Endurance improve DC 22, maintain DC 17, worsen DC 16 or lower
The target is cured. <= Initial Effect: The target begins each day with no action points. Each time the target becomes bloodied, it laughs uncontrollably and is dazed (save ends). Both of these effects apply until the target is cured. <=> The target cannot gain or use action points. <=> Final State: The target is catatonic and unable to take any actions.

Source: DMG, page 49